CompletedPhase 2

Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy

Egypt30 participantsStarted 2021-11-24

Plain-language summary

To evaluate the efficacy and safety of oral Nimodipine and IV milrinone combination therapy for management of cerebral spasm after aneurysmal subarachnoid hemorrhage.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients admitted to our surgical ICU * aged between (18-60) years old * World Federation of Neurological Surgeons grades 1-3 Grades Exclusion Criteria: * Aneurysmal SAH * SAH with Fisher Grade I and IV, * World Federation of Neurological Surgeons grade IV \& V * No informed consent, * peripheral vascular disease * Cardiac disease (heart block, severe valvular stenosis, cardiomyopathothy , ejection fraction\<40%), Renal impairment (serum creatinine ≥ 1.4 mg.L-1), Hemodynamic instability

What they're measuring

Concentration of transcutaneous cerebral mixed oxygen saturation

Timeframe: every 24 hours up to 1 week

Trial details

NCT IDNCT05131867

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2022-05-23

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