Microvascular and Inflammatory Responses of 0.05 Cyclosporine Eye Drop (II) in Treatment of Dry Eye

Inclusion Criteria: * 18-65 years old; * meet the 2-3 grade dry eye diagnosis: 1) At least one eye has one or more ocular discomfort symptoms and OSDI score ≥23; 2) At least one eye meets one of the following two: 2 mm/5min≤Schirmer I test (no anesthesia) \<10 mm/5min; BUT≤10s. 3) Corneal spotting but no extensive erosion. Exclusion Criteria: * Contact lens wearers; * Allergies to the study drug; * Active eye infections; history of serious systemic diseases; * Pregnancy or breastfeeding; * Receiving or starting other treatments that may interfere with the interpretation of the results; * Participating any other clinical trials within 3 months; * Previous eye surgery, including laser treatment and refractive surgery; * Need or have undergone punctal embolization or nasolacrimal duct obstruction; * KCS secondary to the destruction of conjunctival goblet cells (such as vitamin A deficiency) ; * Scar formation (such as cicatricial pemphigus, alkali burn, trachoma or radiation).