Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy

Inclusion Criteria: * Patients undertaking systemic cisplatin therapy as part of their cancer treatment * Age ≥ 18 * Willing to provide informed consent * ECOG performance status 0-2 * For female of child-bearing potential, a negative pregnancy test (beta-HCG) prior to study treatment is required * Any patient who is of reproductive age should provide written agreement to use adequate contraception for the duration of the trial Exclusion Criteria: * Age less than 18 * Preexisting severe to profound sensorineural hearing loss (unilateral or bilateral) (speech reception threshold \>70dB, or word recognition score \<50%) as confirmed with an audiogram * History of Meniere's or fluctuating hearing loss * Asymmetrical hearing loss (bone conduction threshold difference of: (a) 20 dB threshold difference at a single frequency, (b) 15 dB threshold difference at 2 frequencies, (c) 10 dB threshold difference at 3 frequencies * Abnormal renal function (creatinine clearance \<60 ml/min) * Abnormal liver function (liver function tests (ALT and ALP) \>2.5 times upper limit of normal without liver metastasis and \>5 times upper limit of normal with liver metastasis * Previous hypersensitivity to STS or mannitol * Pregnant and/or nursing women * Patient unable to follow the protocol for any reason