PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)

Inclusion Criteria: * Meeting criteria for substance use disorder of methamphetamine in the six months prior to conception or during pregnancy * No active methamphetamine use at time of enrollment or within past 4 weeks prior to enrollment by self-report or urine toxicology. * If diagnosis of active opioid use disorder (OUD) and no use at time of enrollment or within past 4 weeks prior to enrollment by self-report or urine toxicology and on stable dose of medication for OUD (methadone, buprenorphine, naltrexone) for two weeks prior to enrollment in order to allow for postpartum dose adjustments. * Intrauterine device or barrier method for contraception during the study period * End of pregnancy within past 12 weeks * Residing within 100 miles of study site * Stable on allowable psychiatric medications including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and mood stabilizers for four weeks prior to enrollment Exclusion Criteria: * Major medical illness in which progesterone may be contraindicated (significant liver disease, history of thrombophlebitis, stroke, heart disease, suspected or known malignancy, deep vein thrombosis, pulmonary embolus, clotting or bleeding disorders) * Any of the following laboratory abnormalities (within 2 weeks of screening and enrollment) * Active hepatic dysfunction * Anemia defined as hemoglobin less than 8 g/dL indicating anemia * Renal impairment defined as creatinine greater than 2.0 mg/dL * Hypo…