CompletedPhase 4

Ephedrine Versus Ondansetron During Cesarean Delivery

Egypt168 participantsStarted 2022-01-10

Plain-language summary

More than 30% of the patients receiving spinal anesthesia develop hypotension. Hypotension developed during cesarean section (C/S) under spinal anesthesia may jeopardize uteroplacental circulation leading to fetal compromise and even fetal death. The effect of prophylactic ondansetron on blood pressure after spinal anesthesia has not been compared in a clinical trial with that of a vasoconstrictor. The investigators will compare ephedrine and ondansetron for the prevention of maternal hypotension after spinal anesthesia for elective cesarean delivery.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \>18, \<40 years; * American Society of Anesthesiologists physical status I or II; * term pregnancy * singleton pregnancy; * elective cesarean delivery under spinal anesthesia Exclusion Criteria: * Patients with a history of diabetes mellitus other than gestational diabetes, * hypertension, * body mass index \>40 kg/m2, * complicated pregnancy, allergy to study drugs, * long QT syndrome, * Contraindication to spinal anesthesia * Patients who required general anesthesia were withdrawn from the study.

What they're measuring

Incidence of Maternal hypotension

Timeframe: 45 minutes

Trial details

NCT IDNCT05127876

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03-01

View on ClinicalTrials.gov More Spinal Induced Hypotension trials