The prevalence of common mental disorders is high in patients with chronic inflammatory physical diseases(e.g., autoimmune or infectious diseases). The traditional explanatory causation model in which physical symptoms and related disability drive mental health problems is now called into question, and evidence has accumulated supporting more complex interactions whereby psychiatric disorders can both result from and contribute to the progression of physical diseases. In the present project, the investigators will focus on comorbidity of depression and anxiety symptoms or syndromes with chronic inflammatory skin diseases (psoriasis, hidradenitis suppurativa and atopic dermatitis) or chronic infectious diseases (chronic HBV and HIV infection). The study is aimed to clarify the mechanisms underlying the high frequency of those comorbidities. It will overcome the main limitations of previous investigations and use innovative statistical tools to model complex interrelationships and causal links among the assessed variables. The identification of key variables driving the causal chain of determinants of poor global health and quality of life may impact treatment outcome and models of care.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Socio-demographic Data
Timeframe: At recruitment (T0)
Assessment of psoriasis
Timeframe: At recruitment (T0)
Assessment of hidradenitis suppurativa
Timeframe: At recruitment (T0)
Assessment of atopic dermatitis
Timeframe: At recruitment (T0)
Lifetime psychiatric comorbidity
Timeframe: At recruitment (T0)
The Hospital Anxiety and Depression
Timeframe: At recruitment (T0)
Anxiety
Timeframe: At recruitment (T0)
Depression
Timeframe: At recruitment (T0)
Global Physical Assessments: Patient Global Assessment
Timeframe: At recruitment (T0)
Global Physical Assessments: Physician Assessment
Timeframe: At recruitment (T0)
Global Physical Assessments: severity of physical diseases
Timeframe: At recruitment (T0)
Assessment of disability
Timeframe: At recruitment (T0)
Assessment of quality of life
Timeframe: At recruitment (T0)
Neurocognitive domains
Timeframe: At recruitment (T0)
Coping skills
Timeframe: At recruitment (T0)
Stigma
Timeframe: At recruitment (T0)
Plasma levels of IL-1α
Timeframe: At recruitment (T0)
Plasma levels of IL-6
Timeframe: At recruitment (T0)
Plasma levels of TNF-α
Timeframe: At recruitment (T0)
Plasma levels of ICAM-1
Timeframe: At recruitment (T0)
Plasma levels of VCAM-1
Timeframe: At recruitment (T0)
Assessment of D-dimers levels
Timeframe: At recruitment (T0)
Assessment of Fibrogen levels
Timeframe: At recruitment (T0)
Assessment of white blood cells levels
Timeframe: At recruitment (T0)
Assessment of PLT levels
Timeframe: At recruitment (T0)
Assessment CD4 and CD8
Timeframe: At recruitment (T0)
Assessment of hs-CRP levels
Timeframe: At recruitment (T0)
Markers of subclinical inflammatory damage: assessment of subclinical endothelial damage
Timeframe: At recruitment (T0)
Markers of subclinical inflammatory damage: assessment of bone quality
Timeframe: At recruitment (T0)