CompletedNot Applicable

Neural Basis of Sensory and Motor Learning: Functional Connections

United States76 participantsStarted 2022-04-13

Plain-language summary

The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning). The investigators hope this information may be useful one day to improve rehabilitation techniques in patients with brain lesions.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Ages of 18-45 years old * Right-handed. * Free of Covid symptoms in week preceding testing. Exclusion Criteria: * metallic, mechanical, or magnetic implants; * are claustrophobic, or are unable to remain still for long periods of time; * use an intra-uterine device (IUD) whos MR compatibility has not been established. * Women who are pregnant or think they might be pregnant will also be excluded, as effects of fMRI on the unborn are not known. * People who have a BMI over 30 will be excluded as it may be uncomfortable or impossible to lay in the MRI scanner and reach the button box. * Potential subjects will be excluded if they have any neurological disorders, or orthopedic or pain conditions in the upper limbs. * Investigators will also exclude subjects who do not have normal vision, or corrected-to-normal vision with contacts, or the imaging center does not have a pair of MRI compatible glasses that fits their prescription. * investigators will invite subjects to reschedule if they have any of the common Covid symptoms within the last week and if they haven't been fully vaccinated or obtained a negative Covid test within the past 4 days. If they don't believe they can meet these criteria on another date, they will be excluded. * After giving their consent, participants may be excluded during the study if they are unable to perform the tasks or follow instructions.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Resting-state PMv-M1 Functional Connectivity (Fisher Z-transformed Correlation)

Timeframe: 3 scans during the main session (2 hours)

Weighting of Vision vs. Proprioception

Timeframe: Measured during the main session (2 hours)

Trial details

NCT IDNCT05124301

SponsorIndiana University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-13

Results submitted2025-12-15

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