WithdrawnNot Applicable

Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye

Stopped: The Principal Investigator passed away prior to study initiation. The study was withdrawn before enrollment began.

United States0Started 2027-01-01

Plain-language summary

This is a single center double-masked study with up to four visits. Subjects who have been diagnosed with dry-eye syndrome at Flaum Eye Institute will be enrolled. The purpose of the study is to determine if using platelet rich plasma drops can improve clinically significant dry eye in patients and determine if there is a difference with using two different uses of the plasma tear drops: platelet rich plasma tears and plasma tears without platelets.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects must be diagnosed with clinically significant dry eye. * Subjects have no active ocular disease or allergic conjunctivitis. * Subjects must not be using any topical ocular medications within two weeks prior to enrollment. * Subjects must be willing and able to follow instructions. * Subjects must have voluntarily agreed to participate in the study by signing the statement of informed consent. * Subjects must meet plasma donor criteria as established by University of Rochester Transfusion Medicine \& Blood Bank. Exclusion Criteria: * Is pregnant at the time of enrolment in the study determined by urine pregnancy test. * Is currently on a course of antibiotics * Is considered by the Investigator to not be a suitable candidate for participation and are not at risk for glaucoma. * Is considered by the University of Rochester Transfusion Medicine \& Blood Bank not a suitable candidate for blood donation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Mean change in acuity

Timeframe: baseline to 3 months

Mean change in breakup pattern to appear

Timeframe: baseline to 3 months

Mean change in lipid coverage of the cornea with blinking

Timeframe: baseline to 3 months

Mean change in consistency of lipid compensation

Timeframe: baseline to 3 months

Mean change in temperature over the optical service

Timeframe: baseline to 3 months

Trial details

NCT IDNCT05121493

SponsorUniversity of Rochester

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01-15

View on ClinicalTrials.gov More Dry Eye Syndromes trials

Plain-language summary

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Mean change in acuity

Timeframe: baseline to 3 months

Mean change in breakup pattern to appear

Timeframe: baseline to 3 months

Mean change in lipid coverage of the cornea with blinking

Timeframe: baseline to 3 months

Mean change in consistency of lipid compensation

Timeframe: baseline to 3 months

Mean change in temperature over the optical service

Timeframe: baseline to 3 months