CompletedNot Applicable

EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement

Canada58 participantsStarted 2021-11-04

Plain-language summary

This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.

Who can participate

Age range18 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age above 18 years * Undergoing evaluation for chronic liver disease or portal hypertension * Planned to undergo a liver biopsy and HVPG by their treating hepatologist for clinical purposes * Signed informed consent Exclusion Criteria: * Uncorrectable coagulopathy (INR above 1.5) * Uncorrectable thrombocytopenia (Platelets under 50,000) * Anticoagulation or antiplatelet therapy that cannot be discontinued * Surgically altered upper digestive anatomy * Biliary obstruction * Grade II ascites or more * Intrahepatic portal vein thrombosis * Previous liver transplantation * Past hypersensitivity reaction to midazolam or ketamine * History of psychotic disorder * Pregnancy

What they're measuring

Compare the proportion of adequate Liver Biopsy specimens with reliable portal pressure gradient obtained by TJ or EUS

Timeframe: 2 weeks

Trial details

NCT IDNCT05118308

SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-01

View on ClinicalTrials.gov More Portal Hypertension trials