WithdrawnNot Applicable

Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI

Stopped: Inadequate funding

United States0Started 2026-03

Plain-language summary

This study will follow patients admitted to the PICU with sepsis, NICU with sepsis or after abdominal surgery, or CICU who are identified as being at risk for developing acute kidney injury. The investigators will use risk-stratification, biomarker testing, and a functional assessment to predict children and neonates who will become fluid overloaded and develop severe acute kidney injury.

Who can participate

Age range25 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Admitted to the Pediatric Intensive Care Unit (PICU), Cardiac Intensive Care Unit (CICU), or Neonatal Intensive Care Unit (NICU) at participating institution Exclusion Criteria: * Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR \<60 mL/min/1.736m2) * History of kidney transplant within the previous 90 days * Ongoing AKI or Acute Kidney Disease (AKD) at ICU admission requiring renal replacement therapy initiated prior to ICU admission * Acute DNR order or clinical team is not committed to escalating medical care * Anticipated to require intensive care for less than 48 hours

What they're measuring

Clinical Decision Support Performance

Timeframe: Days 2-4 after ICU admission

Trial details

NCT IDNCT05114057

SponsorChildren's Hospital Medical Center, Cincinnati

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-08-31

View on ClinicalTrials.gov More Acute Kidney Injury trials