Decentering and Relapse/Recurrence in MBCT for Depression in Adults (NCT05111665) | Clinical Trial Compass
CompletedNot Applicable
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Canada227 participantsStarted 2008-02-14
Plain-language summary
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions. The current study sought to examine the role of decentering, and other related variables, in the efficacy of Mindfulness-based cognitive therapy (MBCT) as compared to two active comparison conditions.
Method: Formerly depressed individuals (N = 227), randomly assigned to MBCT (n = 74), relaxation group therapy (RGT; n = 77) or treatment-as-usual (TAU; n = 76), completed self-report measures of decentering and symptoms of depression at pre-, mid-, and post-treatment, and relapse was assessed at 3, 6, 9, and 12 months, post-treatment.
Who can participate
SexALL
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Inclusion Criteria:
* a Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM IV-TR; American Psychiatric Association (APA), diagnosis of major depressive disorder (MDD) without psychotic features, in Full Remission;
* three or more prior major depressive episodes;
* age between 18 and 65 years;
* cognitive reactivity (CR) or mood-activated dysfunctional beliefs score greater than or equal to eight (see assessment procedure below);
* a score of less than 10 on the Hamilton Rating Scale for Depression (HRSD);
* minimum of a 10 week period free of psychotropic medication other than stable dosage of antidepressant medication for a minimum of four weeks;
* fluency in English; An increased cognitive reactivity score of eight points or more and,
* ability to give informed consent and complete questionnaires unassisted.
Exclusion Criteria:
* a diagnosis of bipolar disorder (past or present), schizophreniform disorders, substance abuse or dependence (current or within the past six months), borderline or antisocial personality disorder, or neurocognitive disorders;
* current psychotherapy or counselling more frequently than twice per month;
* current practice of meditation more than once per week or yoga more than twice per week;
* electroconvulsive therapy within the past six months; or
* self-reported ingestion of alcohol or other psychoactive substances within the past 48 hrs.
What they're measuring
1
Major depressive disorder (MDD) relapse/recurrence - incidence of
Timeframe: 12- month post-treatment follow-up
2
Change in major depressive disorder (MDD) relapse/recurrence - time to relapse/recurrence
Timeframe: 3-, 6-, 9-, and 12- month post-treatment follow-up