Rapid Diagnosis and Prognosis Recognition of Imaging and Biomarkers in Mild to Moderate Traumatic Brain Injury

Inclusion Criteria: * age 18-75 years at time of recruitment. * Glasgow Coma Scale (GCS) score of 9-15 at the time of informed consent. * non-penetrating TBI resulting from an external force. * diagnosed within 1 week after onset of TBI. * provision of informed written consent. Exclusion Criteria: * acute suspected stroke, neurosurgery, stroke or TIA within the last 30 days. * neurodegenerative disease or other neurological disorder including dementia, Parkinson's disease, multiple sclerosis, seizure disorder, brain tumors. * a history of a previous brain injury, or a history of concurrent substance or alcohol abuse; * the manifestation of TBI caused by medications, alcohol, drugs for other injuries (such as systemic injuries, facial injuries, or intubation). * pregnancy or breastfeeding. * Patients with contraindications to MRI scanning (such as patients with metal implants in their bodies, cardiac pacemakers, dentures, etc.) * participation in a clinical research study with potential to affect the results of this study