Efficacy of a Novel CCH Protocol for PD Among Prior Non-responders

Inclusion Criteria: * Men with Peyronie's Disease * \>18 years old * Curvature ≥30 degrees * Previously completed 6-8 CCH injections * Prior minimal (\<20% and/or \<10 degrees) responsiveness to CCH administration * Prior CCH injections must have been performed without use of a Restorex traction device and used the IMPRESS protocol * Ability to achieve an erection satisfactory for intercourse with or without PDE5 inhibitors * The patient exhibits a palpable plaque consistent with Peyronie's Disease Exclusion Criteria: * Prior surgical treatment on the penis (other than circumcision) * Any contraindications to CCH - as determined by the PI * Inability to complete 8 additional CCH injections * Severe plaque calcification (i.e. \>1 cm shadowing)