Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction (NCT05105529) | Clinical Trial Compass
UnknownNot Applicable
Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction
Canada40 participantsStarted 2021-01-01
Plain-language summary
Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Recreationally active individuals
* Diagnosed asthma and/or mild exercise-induced bronchoconstriction: defined by an FEV1 fall equal to or greater than 10% but lower than 25% in the eucapnic hyperventilatory test.
* Able to securely perform a maximal exercise test (responded 'no' to all questions on the PAR-Q+ questionnaire)
* Able to communicate in English
Exclusion Criteria:
* Diagnosed with any cardiorespiratory or vascular diseases
* Pregnant or potentially pregnant
* Non-smoking
* Lower limb musculoskeletal injury or lower limb limitation to cycle on a bicycle ergometer
* Recent respiratory symptoms or upper tract infection within 4 weeks
* On vitamin (e.g., C or E) supplementation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in FEV1 from baseline to 10 minutes after exercise
Timeframe: Measured at baseline and 10 minutes after each exercise bout
2
Change in FVC from baseline to 10 minutes after exercise
Timeframe: Measured at baseline and 10 minutes after each exercise bout
3
Change in FEF25-75 from baseline to 10 minutes after exercise
Timeframe: Measured at baseline and 10 minutes after each exercise bout