UnknownNot Applicable

Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction

Canada40 participantsStarted 2021-01-01

Plain-language summary

Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Recreationally active individuals * Diagnosed asthma and/or mild exercise-induced bronchoconstriction: defined by an FEV1 fall equal to or greater than 10% but lower than 25% in the eucapnic hyperventilatory test. * Able to securely perform a maximal exercise test (responded 'no' to all questions on the PAR-Q+ questionnaire) * Able to communicate in English Exclusion Criteria: * Diagnosed with any cardiorespiratory or vascular diseases * Pregnant or potentially pregnant * Non-smoking * Lower limb musculoskeletal injury or lower limb limitation to cycle on a bicycle ergometer * Recent respiratory symptoms or upper tract infection within 4 weeks * On vitamin (e.g., C or E) supplementation

What they're measuring

Change in FEV1 from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout

Change in FVC from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout

Change in FEF25-75 from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout

Trial details

NCT IDNCT05105529

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01

Contact for this trial

Patric O Gonçalves, BScPT

6048229331 patricog@alumni.ubc.ca

View on ClinicalTrials.gov More Asthma trials

Plain-language summary

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in FEV1 from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout

Change in FVC from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout

Change in FEF25-75 from baseline to 10 minutes after exercise

Timeframe: Measured at baseline and 10 minutes after each exercise bout