CompletedNot Applicable

TMS for Improving Response Inhibition in Adolescents With OCD

United States7 participantsStarted 2022-04-01

Plain-language summary

The study will examine whether inhibition of the pre-supplementary motor area (pSMA) using transcranial magnetic stimulation (TMS) normalizes activity in pSMA-connected circuits, improves response inhibition, and reduces compulsions in adolescents with OCD.

Who can participate

Age range

13 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 13-18 years * Presence of OCD, as indicated by score on the Children's Yale-Brown Obsessive-Compulsive Scale * Patient and one parent speak English fluently (to ensure comprehension of study measures and instructions * Right-handed * If taking psychotropic medications, these have been stable for \> 6 weeks and are expected to remain stable for the approximately 3-week study protocol * If currently in psychotherapy, symptom improvement has plateaued (no improvement in the past 6 weeks and symptoms expected to remain stable for the approximately 3-week study protocol) Exclusion Criteria: * • Medical conditions contraindicated for TMS or EEG, including history of intracranial pathology, increased intracranial pressure, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, possible pregnancy (female of childbearing age not using effective contraception), or any other serious medical condition (note that medical history will be reviewed by a study physician prior to TMS administration) * Metal in the head, except mouth (e.g., cochlear implant, implanted brain stimulators, aneurysm clips) * Active suicidality or psychosis * Existing diagnosis of Bipolar disorder, Autism Spectrum Disorder, mental retardation, or cognitive disability * Substance abuse or dependence * Taking a stimulant medication (and unwilling to forgo on study visit days) * Taking medication with the potential to lower seizure thresho…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Response Time on Stop Trials of the Stop Signal Task

Timeframe: Change from pre (within 1 hour before) to post (within 1 hour after) intervention

Change in Frontocentral P3 Amplitude on Electroencephalogram (EEG)

Timeframe: Change from pre (within 1 hour before) to post (within 1 hour after) intervention

Trial details

NCT IDNCT05104697

SponsorBradley Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-01

Results submitted2024-11-19

View on ClinicalTrials.gov More Obsessive-Compulsive Disorder trials

Who can participate

Age range

13 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Response Time on Stop Trials of the Stop Signal Task

Timeframe: Change from pre (within 1 hour before) to post (within 1 hour after) intervention

Change in Frontocentral P3 Amplitude on Electroencephalogram (EEG)

Timeframe: Change from pre (within 1 hour before) to post (within 1 hour after) intervention