CompletedPhase 4

Impact of Aripiprazole on Postoperative Analgesia in Laparoscopic Hysterectomy

Egypt80 participantsStarted 2021-11-10

Plain-language summary

The analgesic effect of perioperative use of aripiprazole has not been fully investigated. So, this study aims to test the effects of aripiprazole versus placebo in reducing postoperative pain following laparoscopic hysterectomy and to explore the potential side effects.

Who can participate

Age range40 Years – 65 Years

SexFEMALE

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Inclusion Criteria: * Physical status American Society of Anesthesiologist (ASA) I or II * Electively scheduled for laparoscopic hysterectomy, Exclusion Criteria: * Patients who refuse to participate * Body mass index (BMI) \> 30 * ASA physical status \> II * Diabetes * Major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological) * Coagulation abnormalities * Pregnancy * Known hypersensitivity to aripiprazole or contraindications to its use (a psychiatric illness, patients on antidepressants, dementia-related psychosis) * History of drug addiction or alcohol abuse * Mental retardation interfering with the evaluation of pain scores or PCA programs .

What they're measuring

First time to analgesic requirement

Timeframe: First 24 hours postoperatively

Trial details

NCT IDNCT05103410

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-01

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