This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory performance. iTBS (active or sham) will be administered, then the oscillatory activity of DLPFC and working memory performance will be reassessed. The overarching goal is to determine whether iTBS can acutely enhance the oscillatory activity of the DLPFC and to evaluate the relationship between changes in the DLPFC and working memory performance.
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Change in dorsolateral prefrontal cortex natural frequency (DLPFC NF) following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS
Change in dorsolateral prefrontal event-related spectral perturbation (DLPFC ERSP) following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS
Change in dorsolateral prefrontal inter-trial coherence (DLPFC ITC) following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS
Change in AX-Continuous Performance Task Reaction Time (AX-CPT RT) following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS
Change in AX-Continuous Performance Task Error Rate (AX-CPT ER) following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS
Change in AX-Continuous Performance Task d' context (AX-CPT d') following iTBS
Timeframe: baseline (pre iTBS), within one hour from iTBS