CompletedNot Applicable

Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone for Labor Induction

Greece230 participantsStarted 2021-10-29

Plain-language summary

Acidification of vaginal pH has been proposed as a potential factor that could help increase the efficacy of vaginal prostaglandins in labor induction. The aim of the present randomized controlled trial is to evaluate the impact of an acidic vaginal pH on the progress of labor induction with dinoprostone (Prostaglandin E2 - PGE2) vaginal tablet.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria * Singleton pregnancy * Full term (\>37 weeks) * Cephalic presentation * Reactive NST (nonstress test) * Absence of spontaneous uterine contractions * No contraindications to vaginal delivery Exclusion criteria * Multifetal pregnancy * Fetal malpresentation * Preterm delivery (\<37 weeks) * Advanced maternal age (\>40 years) * Bishop score \> 7 * Fetal macrosomia ( \>4500 gr) * Non reassuring NST (nonstress test) * Suspected chorioamnionitis * Previous cesarean delivery or other uterine surgery

What they're measuring

Interval from induction to delivery

Timeframe: 36 hours

Trial details

NCT IDNCT05100264

SponsorAlexandra Hospital, Athens, Greece

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-29

View on ClinicalTrials.gov More Labor, Induced trials