The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae. This goal will be reached through the harmonization of follow-up strategies across the participating cohorts to allow a standardized collection of data on COVID-19 long-term sequelae. The result will be a platform including a set of data and biomaterials from large scale international cohorts, that will be uniformly recorded, prospectively tracked and analysed. The ultimate goal will be that of providing evidence to contribute to the optimization and improvement of the management and prevention of COVID-19 sequelae. The follow-up will be organized in multiple levels of tests, according to the capability of each cohort, and will include questionnaires to collect demographic, epidemiological and clinical data, physical examination, radiological exams and biological sampling. The long-term follow-up will also allow the assessment of long-term immunological response to SARS-CoV-2 infection and its association to the vaccination and to different treatment strategies, including monoclonal antibodies.
Age range
14 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Clinical assessments of COVID-19 sequelae
Timeframe: 18 months
Laboratory assessments of COVID-19 sequelae
Timeframe: 18 months
Radiological assessments of COVID-19 sequelae
Timeframe: 18 months
Length of COVID-19 sequelae
Timeframe: 18 months
Association between SARS-CoV-2 variants and COVID-19 sequelae
Timeframe: 18 months
Association between immunological patterns and COVID-19 sequelae
Timeframe: 18 months
COVID-19 reinfections
Timeframe: 18 months
Patterns of intestinal microbiome after SARS-CoV-2 infection
Timeframe: 18 months
Patterns of pulmonary microbiome after SARS-CoV-2 infection
Timeframe: 18 months
Human and viral genetic markers related to disease severity
Timeframe: 18 months