The purpose of this trial is to explore mifepristone as an option for induction of labor at term by evaluating the efficacy of mifepristone use for cervical preparation. Since the Labor Induction versus Expectant Management in Low-Risk Nulliparous Women (ARRIVE) trial supporting that elective induction after 39 weeks decreases cesarean sections and morbidity, rates of elective term inductions are increasing. At Lucile Packard Children's Hospital at Stanford University specifically, approximately 40% of spontaneous vaginal deliveries follow induction of labor, with an average induction time of 20 hours. Previous studies have established the maternal and neonatal safety of mifepristone in term inductions, however, this study will assess the difference in overall time from induction to complete cervical dilation, delivery, and the total time on Labor and Delivery.
Age range
18 Years – 45 Years
Sex
FEMALE
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Uterine Contractions
Timeframe: Up to approximately 72 hours, from start of labor induction to removal of transcervical balloon
Number of Participants With Uterine Tachysystole
Timeframe: Up to approximately 72 hours from start of labor induction
Number of Minutes in Hypertonus
Timeframe: Up to approximately 72 hours, from start of labor induction until the time of delivery
Time to Complete Cervical Dilation
Timeframe: Up to approximately 72 hours from start of labor induction
Time to Delivery
Timeframe: Up to approximately 72 hours, from start of labor induction until the time of delivery
Total Labor and Delivery Unit Admission Duration Time
Timeframe: Up to approximately 80 hours after the time of Labor and delivery admission
Number of Patients Who Undergo Cesarean Delivery
Timeframe: Up to approximately 72 hours from start of labor induction
Number of Patients Able to Achieve Active Labor
Timeframe: Up to approximately 72 hours from start of labor induction
Number of Patients With Severe Maternal Morbidity
Timeframe: Up to approximately 1 week after hospital admission for delivery
Mean Neonatal Arterial Cord Blood pH
Timeframe: Within approximately 2 hours after delivery (approximately 5 minutes to obtain sample)
Number of Participants With Neonatal APGAR Score <7
Timeframe: At 1 minute and 5 minutes of infant life (approximately 10 seconds to perform each assessment)
Number of Patients With Serious Neonatal Morbidity
Timeframe: Up to 7 days after birth