CompletedNot Applicable

Physical Activity, Air Pollution, and High Blood Pressure

Canada21 participantsStarted 2021-11-15

Plain-language summary

The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. Participants will be exposed to 2 conditions: a low TRAP environment and a high TRAP environment. Each exposure will consist of 30 min of moderate-intensity exercise. Cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. A minimum washout period of 1 week will be used to minimize carryover effects.

Who can participate

Age range40 Years – 70 Years

SexALL

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Inclusion criteria

✓. Age between 40-70 years of age
✓. Previously diagnosed with elevated blood pressure or hypertension by a physician

Exclusion criteria

✕. Current or ex-smokers (abstinent for less than one year)
✕. Lives with an individual who currently smokes cigarettes, e-cigarettes (i.e., vaping), or cannabis
✕. Hormone replacement therapy use
✕. Currently on beta-blocker or angiotensin receptor blocker (ARB) therapy
✕. Currently using over the counter drugs or supplements that may alter cardiovascular measures (as per the principal investigator's discretion)
✕. Prior diagnosis of any other existing cardiovascular or pulmonary diseases and/or conditions (other than hypertension)
✕. Musculoskeletal injury or lower limb limitation preventing safe engagement in moderate-intensity exercise

What they're measuring

Change from Baseline Blood Pressure at 2 Hours Post-Exposure

Timeframe: Baseline and 2 hours post-exposure

Trial details

NCT IDNCT05092672

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-08-01

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