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Study on Correlation Between Cytomegalovirus and Ocular Myasthenia Gravis

China125 participantsStarted 2021-01-01

Plain-language summary

Ocular myasthenia gravis (OMG) is an autoimmune neuromuscular disease mediated by pathogenic autoantibodies. Its etiology and pathogenesis are not completely clear. The occurrence and development of OMG are the result of the joint participation of genetic factors, environmental factors and immune factors. The role of infectious factors in the pathogenesis of autoimmune diseases is a hot topic in the international discussion.By analyzing the difference in the positive rate and titer of CMV antibodies between ocular myasthenia gravis and healthy people. By analyzing the correlation between the positive rate and titer of CMV antibodies and ocular myasthenia gravis clinical manifestations, acetylcholine receptor antibodies, ESR, hypersensitive C-reactive protein, complement C3, complement C4 and thymus status.To investigate the correlation between cytomegalovirus and ocular myasthenia gravis. It can provide new insights for further studies on the etiology and possible pathogenesis of ocular myasthenia gravis.

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

the patience group Inclusion criteria: * Clinical manifestations: fluctuating eye muscle weakness; * Positive ice test, fatigue test, rest and sleep test; * Positive neostigmine test; * Serum acetylcholine receptor antibody and other antibodies are positive; * Repeated electrical nerve stimulation test attenuation is positive; * Meeting the above diagnostic criteria of the first, or any of the other 4, at the same time excluding other diseases caused by eye palsy can be clear diagnosis. the patience group exclusion criteria: * General myasthenia gravis; * History of other eye diseases * With other autoimmune diseases or other inflammatory diseases; * Patients with diabetes, hypertension, coronary heart disease and other chronic medical history or cancer diseases; * Hepatitis B virus, hepatitis C virus, HIV, syphilis positive patients; * immunosuppressive drugs (such as glucocorticoid, azathioprine and cyclosporine A), gamma globulin for intravenous injection, plasmapheresis, etc., within 3 months before treatment; * Previous thymic resection or thymus radiation therapy; * Pregnancy or lactation. the control group Inclusion criteria: * No obvious abnormality was found in the recent physical examination results; * No history of autoimmune diseases; * Have not received antiviral therapy or immunotherapy within 3 months; * No history of other eye diseases or systemic diseases.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

CMV lgG, lgM positive rate

Timeframe: 1year

CMV lgG, lgM antibody titer

Timeframe: 1year

Trial details

NCT IDNCT05091177

SponsorXiaoYong Liu

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

View on ClinicalTrials.gov More Ocular Myasthenia Gravis trials