Novel Non-opioid Post-surgical Pain Treatment in Females

Inclusion Criteria: * female with no racial or ethnic restrictions; * 18 to 75 years old; * Have a bunionectomy or toe fusion surgery scheduled; * must be able to read, understand, and sign consent form; * generally healthy. Exclusion Criteria: * Chronic neurologic conditions, e.g., Parkinson's * pregnancy; * opioids use 60 mg/day oral morphine milligram equivalent.; * use of anticoagulants (low dose ASA allowed); * history of gastric ulcer; renal insufficiency or congestive heart failure, * contraindication to study medication as determined by surgeon * Any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk * In the judgment of the investigator, unable or unwilling to follow protocol and instructions; * Diagnosis of psychological diseases, such as major depression; bipolar disorder.