CompletedPhase 4

Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

Canada18 participantsStarted 2021-11-01

Plain-language summary

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

Who can participate

Age range18 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Have asthma and/or EIB * Able to perform maximal exercise * Able to communicate sufficiently using the English language Exclusion Criteria: * Allergic to salbutamol (also known as Ventolin) * Pregnant or potentially pregnant * Have a history of smoking * Had an upper respiratory tract infection within the last 4 weeks * Have a chronic respiratory disease other than asthma or EIB

What they're measuring

Measured Before and 30 Minutes After Exercise in Each 1 Day Condition

Timeframe: Measured before and 30 minutes after exercise in each 1 day condition

Change in FVC From Baseline to 30 Minutes After Exercise

Timeframe: Measured before and 30 minutes after exercise in each 1 day condition

Trial details

NCT IDNCT05087693

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-31

Results submitted2024-04-04

View on ClinicalTrials.gov More Asthma and/or Exercise Induced Bronchoconstriction trials