CompletedEarly Phase 1

Zinc Effect on Inflammation and Cardiovascular Risk in HIV

United States95 participantsStarted 2020-01-22

Plain-language summary

To study the effect of short-term zinc supplementation on improving inflammation, metabolic, and cardiovascular risk among HIV infected patients on stable anti-retroviral therapy

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * HIV-1 infection * Documentation of an HIV-1 RNA level of ≤400 copies/mL in the last 4 months prior to study entry * Male or Female age ≥18 years * Zinc level ≤0.75 mg/L in the last 60 days Exclusion Criteria: * Pregnancy/lactation * Known cardiovascular disease * Uncontrolled diabetes

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Effect of Zinc Supplementation on Zinc Levels at 24 Weeks in HIV-infected Subjects

Timeframe: between baseline and 24 weeks

Effect of Zinc Supplementation on Inflammation and Immune Activation in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks

Effect of Zinc Supplementation on Inflammation in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks

Effect of Zinc on oxLDL in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks

Trial details

NCT IDNCT05085834

SponsorUniversity Hospitals Cleveland Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-08-02

Results submitted2025-05-01

View on ClinicalTrials.gov More Inflammation trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Effect of Zinc Supplementation on Zinc Levels at 24 Weeks in HIV-infected Subjects

Timeframe: between baseline and 24 weeks

Effect of Zinc Supplementation on Inflammation and Immune Activation in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks

Effect of Zinc Supplementation on Inflammation in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks

Effect of Zinc on oxLDL in HIV-infected Subjects

Timeframe: between baseline and 24 Weeks