UnknownNot Applicable

Pathogen Detection in HIV-infected Children With Non-malarial Febrile Illnesses Using Metagenomic Sequencing

Uganda138 participantsStarted 2023-01-01

Plain-language summary

In Uganda, 130,000 children (0-14 years of age) were living with HIV in 2018. Last year, nearly 450 infants acquired HIV every day; most of them during childbirth and these are at extremely high risk of dying in the first two years of life from treatable infections which present with fever. While fevers are commonly attributed to malaria, most fevers in African children are not due to malaria and clinicians are challenged by the similar clinical features of wide spectrum of potential aetiologies. The prevalence of treatable causes of non-malarial febrile illnesses in children in Africa has been reported to be 45%.

Who can participate

Age range3 Months – 14 Years

SexALL

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Inclusion Criteria: Study population will include a total of 200 (100 who are \<5 years and 100 who are 6-to-14 years, including equal number of female and male study participants) HIV-infected Ugandan children and adolescents admitted with non-malarial febrile illnesses (NMFIs) to Baylor College of Medicine Children's Foundation - Uganda. Exclusion Criteria: Critically ill patients will not be recruited.

What they're measuring

Prevalence of microbial pathogens in NMFIs HIV-infected children and adolescents

Timeframe: 36 months

Trial details

NCT IDNCT05085158

SponsorMakerere University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-30

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