Improvement in the Appearance of Periorbital Wrinkles

Inclusion criteria

• ✓. Having no uterus
• ✓. No menses for at least 12 months
• ✓. Bilateral tubal ligation Or; (WOCBP) women of childbearing potential, must have had a regular menstrual cycle prior to study entry. All systemic birth control measures must be in consistent use at least 6 months prior to study participation. WOCBP must agree to use an effective method of birth control during the course of the study, such as:
• ✓. Oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine device
• ✓. Intrauterine coil
• ✓. Barrier method used with an additional form of contraception (e.g., sponge, spermicide or condom)
• ✓. Abstinence or same sex partner (If practicing abstinence or sexual activity with a same sex partner, must agree to use barrier method described above (c) if becomes sexually active with a non-vasectomized male partner).
• ✓. Vasectomized male partner (for at least 6 months) (must agree to use barrier method described above (c) if becomes sexually active with un-vasectomized male partner).