Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals

Inclusion Criteria: * Generally healthy males and females ≥18 years of age. * Able to read, sign and receive a copy of the signed informed consent form. * Have at least 20 natural teeth. Exclusion Criteria: * Clinically visible active caries lesions and/or periodontitis. * Significant oral soft tissue pathology based on a visual examination. * History of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or chewing gum or their ingredients. * History of allergies to ingredients in the test product. * Self-reported as pregnant or nursing. * Self-reported serious medical conditions. * Antibiotic or anti-inflammatory medication within 30 days of screening visit. * Orthodontic appliances, including retainers, peri/oral piercings, or removable partial dentures. * Acute sinusitis or severe oral-pharyngeal infections.