CompletedNot Applicable

Dysregulated Urea-synthesis at Terminal Uremia

Denmark10 participantsStarted 2022-03-01

Plain-language summary

This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> or equal to 18 years * Chronic hemodialysis during 3 months * Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby" Exclusion Criteria: * Active infection * Conditions with vomiting or diarrhea * Diabetes * Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included. * Liver disease * Vessels on the upper extremities not suited for cannulation * Prednisolone treatment during the last 8 weeks * Pregnancy * BMI \> or equal to 30 or \< or equal to 18 * Physically or mentally condition that does not allow the project to be completed * Language-difficulties that does not allow the project to be completed

What they're measuring

Urea synthesis rate during alanine infusion

Timeframe: 4 hours. 1 hour of blood sample measuring of baseline urea-synthesis rate and 3 hours of urea-synthesis rate during alanine-infusion

Trial details

NCT IDNCT05076318

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-01

View on ClinicalTrials.gov More Urea Cycle Disorder trials