UnknownNot Applicable

Application of Hyaluronic Acid in the Treatment of Periodontitis

Italy80 participantsStarted 2023-01-01

Plain-language summary

The aim of the present investigation will be evaluated the healing of suprabony defects following surgical flap elevation and hyaluronic acid application respect to surgical flap elevation alone. A total of 80 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: hyaluronic acid group and no-hyaluronic acid group.

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients diagnosed with periodontitis * Age ≥ 18 years old * Single-rooted and multi-rooted teeth * Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation * Intrabony defect with an intraosseous component \< 2 mm Exclusion Criteria: * Patients with systemic diseases * Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery * Pregnant or lactating * Tobacco smokers (≥ 10 cigarettes per day) * Multi-rooted teeth with furcation involvement * Increased tooth mobility (grade II and III)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change of Clinical Attachment Level (CAL) gain (millimeters)

Timeframe: baseline, 6 months after surgical periodontal therapy

Trial details

NCT IDNCT05073575

SponsorFederico II University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-01

Contact for this trial

Luca Ramaglia

+393476912911 luca.ramaglia@unina.it

View on ClinicalTrials.gov More Periodontal Bone Loss trials