Application of Hyaluronic Acid in the Treatment of Periodontitis

Inclusion Criteria: * Patients diagnosed with periodontitis * Age ≥ 18 years old * Single-rooted and multi-rooted teeth * Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation * Intrabony defect with an intraosseous component \< 2 mm Exclusion Criteria: * Patients with systemic diseases * Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery * Pregnant or lactating * Tobacco smokers (≥ 10 cigarettes per day) * Multi-rooted teeth with furcation involvement * Increased tooth mobility (grade II and III)