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Optimizing Antibiotic Use in Neonatal Intensive Care Units in China

China10,000 participantsStarted 2021-10-01

Plain-language summary

This project aims to reduce antibiotic use in Chinese neonatal intensive care units (NICU) by 1) developing an adaptable framework of NICU-targeted antimicrobial stewardship programs (ASP); 2) implementing the NICU-targeted ASP in NICUs using a collaborative quality improvement method; and 3) evaluating the impact of ASP implementation on neonatal antibiotic use.

Who can participate

Age range0 Days – 120 Days

SexALL

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Inclusion Criteria: * All infants born at ≤31+6 weeks' gestation and admitted to the participating NICUs between October 1st, 2019 and September 30th, 2023. * The period from October 1st, 2019 to September 30th, 2021 will be used as the baseline period before ASP intervention. Clinical data of eligible infants in this period will be retrospectively collected from a previously established database of preterm infants. * The ASP implementation will be initiated on October 1st, 2021. The period from October 1st, 2021 to September 31st, 2023 will be the ASP intervention period and data will be prospectively collected. Exclusion Criteria: * Infants who are transferred to non-participating NICUs within 24 hours after birth.

What they're measuring

Total antibiotic days of therapy (DOT) per 1000 patient-days

Timeframe: up to 180 days

Trial details

NCT IDNCT05073549

SponsorChildren's Hospital of Fudan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-30

Contact for this trial

Siyuan Jiang, PhD

8613761644971 jiangsiyuan@fudan.edu.cn

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