CompletedPhase 2

The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy.

Saudi Arabia37 participantsStarted 2020-12-08

Plain-language summary

A double-blind randomized clinical trial was conducted for 14 days with 37 systemically healthy patients having chronic generalized gingivitis. The current study was designed to investigate the anti-inflammatory and antimicrobial efficacy of Nigella Sativa oil compared with chlorohexidine; assessing clinical parameters and gingival interleukin 6 (IL6) and interleukin 18 (IL18) levels and supra-gingival plaque analysis.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 20 natural teeth * Patients with moderate to severe gingivitis * No tooth attachment loss Exclusion Criteria: * Periodontitis * Cigarette smokers * Antibiotic therapy (within the last 3 months) * Systemic diseases * Pregnant women * Lactating women * Current orthodontic treatment * Using an intra-oral artificial prosthesis * Using other chemical agents as a mouthwash

What they're measuring

Gingival index

Timeframe: Day 0 and day 15

Plaque index

Timeframe: Day 0 and day 15

IL-6 levels

Timeframe: Day 0 and day 15

IL-18 levels

Timeframe: Day 0 and day 15

Trial details

NCT IDNCT05069246

SponsorIshrat Rahman

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-24

View on ClinicalTrials.gov More Gingivitis trials