TerminatedNot Applicable

Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules

Stopped: Withdrawal by sponsor

United States31 participantsStarted 2021-09-23

Plain-language summary

The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at determining whether a lung nodule is cancerous when compared to a PET/CT scan alone. A PET/CT scan is already used for diagnosis of lung nodules, but its efficacy is uncertain in nodules 6-20 mm in size. Therefore, the PET/CT will be evaluated for its diagnostic ability in lesions this size alone and in combination with a liquid biopsy. Secondarily, a machine learning model will be created to see if the combination of the PET/CT imaging data and the liquid biopsy data can predict the presence of cancer.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. At least one solid lung nodule measuring 6 mm- 20 mm in greatest diameter detected on screening CT
✓. No single lesion larger than 20 mm in greatest diameter when multiple nodules present
✓. High- or intermediate-risk nodules per American College of Chest Physician (ACCP) guidelines

What they're measuring

Comparison of liquid biopsy with PET/CT to PET/CT alone for predicting lung cancer

Timeframe: 24 months

Trial details

NCT IDNCT05066776

SponsorPalo Alto Veterans Institute for Research

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-02-01

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