CompletedPhase 4

Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine

113 participantsStarted 2013-05-01

Plain-language summary

Sugammadex may prevent residual neuromuscular blockade by providing rapid reversal at the end of the operation. Our goal is to compare the half-dose use of sugammadex for reversing residual blockade after administration of neostigmine and atropine to the routine use of reversal medication.

Who can participate

Age range

40 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Inclusion criteria: * 40 and 65 years of age, * American Society of Anesthesiologists Physical Status (ASA-PS) of 3 and 4, * Elective lower gastrointestinal tumor resection surgeries, * Supine positioning, * Surgery requiring use of general anesthesia and muscle relaxation, * Use of inhalational agent of sevoflurane anesthesia, * Surgical duration of about three to six hours. Exclusion Criteria: * History of known or suspected neuromuscular disease, * History of renal or hepatic dysfunction, * Hyperkalemia, * Patients receiving antibiotics, anticonvulsants, or magnesium, * History of stroke, * History of glaucoma, * History of pregnancy or breastfeeding, * Suspicion of abdominal infection or sepsis, * Suspected history of malignant hyperthermia, * An allergy to medications used during general anesthesia

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Incidence of postoperative residual neuromuscular blockade (rNMB)

Timeframe: After operation within 24 hours

Recovery time-1

Timeframe: After operation within 120 minutes

Recovery time-2

Timeframe: After operation within 120 minutes

Recovery time-3

Timeframe: After operation within 24 hours

Muscle strength after extubation

Timeframe: After operation within 24 hours

Trial details

NCT IDNCT05066035

SponsorKartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2016-10-01

View on ClinicalTrials.gov More Neuromuscular Blockade trials

Who can participate

Age range

40 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Incidence of postoperative residual neuromuscular blockade (rNMB)

Timeframe: After operation within 24 hours

Recovery time-1

Timeframe: After operation within 120 minutes

Recovery time-2

Timeframe: After operation within 120 minutes

Recovery time-3

Timeframe: After operation within 24 hours

Muscle strength after extubation

Timeframe: After operation within 24 hours