RecruitingNot Applicable

Amygdala Memory Enhancement

United States90 participantsStarted 2021-11-01

Plain-language summary

The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Must be able to understand and speak English. * Able to provide informed consent. * Diagnosed with epilepsy. * Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization. * Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices. Exclusion Criteria: * Unable to understand and speak English. * Unable to provide informed consent. * Not diagnosed with epilepsy.

What they're measuring

Free recall memory discriminability index (proportion recalled)

Timeframe: 5 years

Recognition memory discriminability index (proportion recalled)

Timeframe: 5 years

Trial details

NCT IDNCT05065450

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-01

Contact for this trial

Joan Atencio

314-362-3114 atencio@wustl.edu

View on ClinicalTrials.gov More Brain Diseases trials