WithdrawnNot Applicable

An Investigational Scan (MR DENSE) in Detecting Early Chemotherapy-Related Liver Injury Before Surgery in Patients With Resectable Colorectal Liver Metastases

Stopped: Overall Recruitment Status Withdrawn no participants

0Started 2018-07-12

Plain-language summary

This trial studies how well a magnetic resonance imaging technique called Displacement Encoding with Stimulated Echo (DENSE) works in detecting chemotherapy-related liver injury in patients with colorectal cancer that has spread to the liver and can be removed by surgery. Researchers want to learn if the DENSE technique improves the standard MRI method.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients treated with neoadjuvant chemotherapy and scheduled for hepatectomy, per standard of care at our institution, and meet criteria for hepatectomy. * No contraindications to MRI (such implanted ferromagnetic or pump devices, metallic fragments in eye), as indicated on our departmental MRI screening form. * Patient who is able to undergo informed consent. * Men and non-pregnant women. * Metastatic disease limited to liver. * Metastases involving no more than 6 liver segments. * No radiographic evidence of involvement of the hepatic artery, major bile ducts, main portal vein, celiac/para aortic lymph nodes. Exclusion Criteria: * Contraindication to MRI. * Inability to comply with study and/or follow-up procedures. * Unable to provide informed consent. * Presence of extrahepatic metastatic disease. * Metastases involving more than 6 liver segments. * Radiographic evidence of involvement of the hepatic artery, major bile ducts, main portal vein, celiac/para aortic lymph nodes. * Pregnant women.

What they're measuring

Magnetic Resonance Displacement Encoding with Stimulated Echo (MR DENSE) imaging data of patients treated with chemotherapy prior to resection of metastases to explore its utility in detecting sinusoidal liver injury.

Timeframe: through study completion, an average of a year.

Trial details

NCT IDNCT05059717

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-24

View on ClinicalTrials.gov More Colorectal Carcinoma Metastatic in the Liver trials