The Women TDF-FTC Benchmark Study

Inclusion Criteria: * Age ≥18 and ≤30 years old * Willing to undergo urine pregnancy tests * Has understood the information provided and has provided written informed consent before any study-related procedures are performed. * HIV uninfected based on negative HIV rapid tests, according to Kenyan national algorithm * Normal renal function (estimated glomerular filtration rate \>60 mL/min) * Hepatitis B surface Ag negative * No active clinically significant medical or psychiatric conditions that would interfere with study participation * Lack of severe anemia * Willing to use DOT and come to clinic frequently for DOT PrEP for at least 8 weeks * Willing to have home visits for follow up * Has access to an active smartphone to allow off-site observation of dosing if unable to come to the clinic or as determined by the study staff, the participant resides in close location to clinic to permit home visit if unable to come to the clinic. i.e., potential participants without a smartphone may be enrolled in the study if investigator determines that the participant resides within reasonable distance from the clinic that would permit home visit id the participant misses their visit. * Intention to stay within the study site's catchment area for at least 8 weeks. * Resides or works in catchment area with high speed internet coverage to permit video streaming Specific for non-pregnant cisgender women cohort * Not pregnant or breast feeding * At low risk for HIV. In Kenya, national gui…