Wide Excision of Soft Tissue Sarcomas in Combination With Interstitial Radiation Therapy

Inclusion Criteria: * C49.1 Malignant neoplasm of the connective and soft tissues of the upper limb, including the shoulder girdle * C49.2 Malignant neoplasm of the connective and soft tissues of the lower limb, including the hip region * Tumor size 7 cm or less * For malignant tumors: Grade 2-3 * Locally advanced soft tissue sarcomas * Absence of regional metastases * Tumor recurrence Exclusion Criteria: * Children, women during pregnancy, childbirth, women during breastfeeding. * Military personnel, with the exception of contract military personnel. * Persons with mental disorders. * Persons detained, taken into custody, serving a sentence in the form of restriction of freedom, arrest, imprisonment or administrative arrest. * The age of patients is under 18 years old * Histologically confirmed diagnosis of GIST, Kaposi's sarcoma, alveolar, clear cell sarcoma, chondrosarcoma, paraossal osteosarcoma * Inoperable tumor * A tumor with decay or with the threat of decay * The presence of damage to the skin in the affected area * The presence of a second malignant tumor * Having an active or chronic fungal / bacterial / viral infection * Uncontrolled chronic diseases of the liver, kidneys in the acute stage * Superficial tumor (within the skin) * The use of a reconstructive plastic component using a displaced musculocutaneous flap * The use of vascular prosthetics * The removed tumor bed is more than 7 cm * The presence of a tumor growing into the bone * The presence of blood v…