CompletedNot Applicable

The Effect of Root-canal Medicaments on Post-operative Pain in Re-treatment Cases

Turkey (Türkiye)120 participantsStarted 2019-03-23

Plain-language summary

This randomized clinical trial compares the effects of intracanal medicaments on the incidence of postoperative pain and flare-up in asymptomatic retreatment cases.

Who can participate

Age range

20 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients between 20 - 65 years of ages
. Patients who agree to participate this study
. Not taking analgesic or antibiotics in the last week
. Single root and single-canal incisor, canine, premolar teeth that have been treated only once before
. Teeth with previous endodontic treatment but with insufficient root canal filling on radiographic examination
. Teeth with periapical lesions and at least 2 years since the previous treatment, although root canal filling seems sufficient
. Periapical radiolucency, teeth with increased or unchanged according to pre-treatment radiography (if available)
. Teeth are asymptomatic

Exclusion criteria

. Pregnant patients and patients in lactation period
. Having used corticosteroids in the last 6 months
. Individuals with systemic diseases (endocarditis, immune system diseases,etc.) requiring antibiotic prophylaxis

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 6th hours.

Timeframe: 6 th hours

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 12 th hours.

Timeframe: 12 th hour

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 24th hours.

Timeframe: 24 th hour

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 2nd days.

Timeframe: 2nd days

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 3th days.

Timeframe: 3th days

Pain level comparison after the application of three different root canal medicaments in root canal : VAS (Visual Analogue Scale) at 4th days.

Timeframe: 4th days

Trial details

NCT IDNCT05052814

SponsorAydin Adnan Menderes University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-06-23

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