CompletedPhase 2/3

Evaluation of Antibacterial Effect of Allium Sativum, Calcium Hydroxide and Their Combination in Infected Mature Teeth

Egypt48 participantsStarted 2019-10-08

Plain-language summary

This study was to evaluate and compare garlic extract antibacterial effect when used as an intra-canal medicament in infected mature anterior teeth with calcium hydroxide and a mixture of calcium hydroxide and garlic, using real time PCR analysis.

Who can participate

Age range10 Years – 13 Years

SexMALE

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Inclusion criteria

✓. Cooperative male children with age ranging from 10 to 13 years.
✓. All patients should have pulp necrosis with apical periodontitis in one or more upper incisor(s).
✓. Teeth included in the study were preliminarily evaluated by preoperative periapical radiographs and should have: single canal (type I vertucci's classification) with closed apices, periapical lesions of endodontic origin with a diameter ranging from 2 to 5 mm without any previous RCT procedure.

Exclusion criteria

✕. immune-compromised patient or patient with complicating systemic disease.
✕. Patients received antibiotic therapy within the previous 3 months.
✕. Tooth having gross carious lesions, fractures or cracks involving the periodontium (un-restorable tooth).
✕. Tooth with root canal calcifications or resorption

What they're measuring

Test the antibacterial efficiency of Garlic extract as intracanal medicament in comparison to Calcium hydroxide and their combinations , against E.faecalis and streptococcus bacteria using qRT-PCR analysis.

Timeframe: 12 months

Trial details

NCT IDNCT05050071

SponsorSuez Canal University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-08

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