CompletedNot Applicable

Adverse Childhood Experiences in Alcohol Use Disorder

Germany43 participantsStarted 2021-11-22

Plain-language summary

Adverse childhood experiences (ACE) and their relation to the development of an alcohol use disorder (AUD) will be measured with functional magnetic resonance imaging (fMRI).

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: * Male and female * Age between 18 and 65 * Normal or correctable eyesight * Sufficient ability to communicate with the investigators, to answer questions in oral and written form * "Fully Informed Consent" * "Written Informed Consent" * Individuals with alcohol use disorder according to DSM-5 or 'heavy drinking' (alcohol intake \> 40g/ more than 5 days (women) \& 60g/ more than 5 days (men) and varying levels of adverse childhood experiences Exclusion Criteria: * Withdrawal of the declaration of consent * Exclusion criteria for an MRI scan (pregnancy, metal implants, etc.) * Severe internal, neurological and psychiatric comorbidities * Pharmacotherapy with psychoactive substances within the last 14 days (except treatment with SSRI/SNRIs for at least 28 days) * Axis-I disorder according to ICD-10 and DSM 5 (except tobacco and alcohol use disorder, substance abuse with less than 2(11) criteria according to DSM-5, mild depressive episode, adaptation disorder and specific phobia within the last 12 months) * Positive urin drug screening (cannabis, amphetamine, opiates, benzodiazepines, cocaine) * Withdrawal symptoms (CIWA-R \> 7) * Intoxication at time of investigation (breathalyzer \> 0.3‰) * Suicidal tendency or potential danger for others

What they're measuring

fMRI to assess group and within-subjects differences in task-specific brain activation patterns: Stress-sensitivity

Timeframe: fMRI measurement at one day only (day of fMRI experiment)

fMRI to assess group and within-subjects differences in task-specific brain activation patterns: Emotion processing

Timeframe: fMRI measurement at one day only (day of fMRI experiment)

fMRI to assess group and within-subjects differences in task-specific brain activation patterns: Alcohol cue-reactivity

Timeframe: fMRI measurement at one day only (day of fMRI experiment)

fMRI to assess group differences in task-specific brain activation patterns: Response inhibition

Timeframe: fMRI measurement at one day only (day of fMRI experiment)

fMRI to assess group differences in task-specific brain activation patterns: Working memory

Timeframe: fMRI measurement at one day only (day of fMRI experiment)

Long-term alcohol consumption

Timeframe: 2 - 2.5 year follow-up after first project

Short-term alcohol consumption

Timeframe: 3-month follow-up after current project

Trial details

NCT IDNCT05048758

SponsorCentral Institute of Mental Health, Mannheim

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-01-17

View on ClinicalTrials.gov More Alcohol Use Disorder trials