Active — Not RecruitingNot Applicable

The Impact of Malnutrition on Immune Responses to Tuberculosis

India200 participantsStarted 2020-08-01

Plain-language summary

The aim of this study is to assess immune responses to Mtb in children with MAM compared to well-nourished children and to evaluate the impact of a nutrition intervention on these immune responses.

Who can participate

Age range12 Months – 60 Months

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 12-60 months * HIV-negative * BCG vaccinated * Moderate acute malnutrition (WHZ -2 to -3 or MUAC 115 - 125mm ± HAZ \<-2) * TB disease * Latent TB infection Exclusion Criteria: * Inclusion criteria not met * Severe acute malnutrition (WHZ\<-3; MUAC\<115mm; bilateral oedema) * Severe anaemia (Hb: \<7g/dl) * Chronic infection (HIV, hepatitis B or C) * Chronic disease (e.g. Crohn's disease) * Feeding problems (eg cerebral palsy) that prevent ingestion of RUSF * Known nut allergy * MDR TB disease and contacts of MDR TB adults

What they're measuring

IFNγ concentration

Timeframe: 6 months

Trial details

NCT IDNCT05044910

SponsorTuberculosis Research Centre, India

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2024-08-31

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