The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Changes in graded exercise stress test
Timeframe: 16 weeks
Retinal microvascular density changes
Timeframe: 16 weeks
Cognitive changes
Timeframe: 16 weeks
Serum growth factor changes
Timeframe: 16 weeks