CompletedNot Applicable

Epidural Nalbuphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Lower Limb Surgeries

Egypt23 participantsStarted 2021-10-01

Plain-language summary

Combined spinal epidural anesthesia (CSE) with bupivacaine alone is not sufficient to cover pain sequel during lower limb surgeries. Previous studies used addition of either Nalbuphine or dexmedetomidine to bupivacaine in epidural anesthesia giving a good result in pain control. In this study the investigators will evaluate and compare the addition of either Nalbuphine or dexmedetomidine to bupivacaine in epidural anesthesia to evaluate the analgesic efficacy of either drug.

Who can participate

Age range21 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patient acceptance. * BMI 25-29.9 kg/m2. * ASA I and ASA II. * Scheduled for elective lower limb orthopedic surgeries under (CSE) block. Exclusion Criteria: * Patient with known allergy to study drugs, * Patients suffering from severe chronic diseases (cardiac, renal, hepatic and neurological or diabetes), * Patients with infection at the site of spinal-epidural block, * Drug addict patients, * Patients on long term steroid therapy, * Patients with abnormalities in vertebral spine, * Mentally retarded or uncooperative patients, * Patients receive anti-coagulant therapy or suspected coagulopathy.

What they're measuring

Duration of epidural analgesia

Timeframe: within 24 hour postoperative

Maximum level of sensory blockade

Timeframe: after 30 min of administering the local anesthetic in the epidural space

Trial details

NCT IDNCT05041270

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2022-04-30

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