Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome

Inclusion Criteria: * Age ≥ 18 years old. * The clinical symptoms and signs are consistent with acute anterior circulation large vessel occlusion; * NIHSS score ≥ 10 points; * (Level of consciousness) NIHSS score 0 or 1; * The time from onset to randomization is within 6 hours of onset; * The mRS score before stroke is 0-1; * The patient has good compliance and can complete the operation with local anesthesia; * The patient can cooperate with this study and follow-up in the future * Patient and family members sign informed consent。- Exclusion Criteria: * Rapid neurological function improvement, NIHSS score less than 10 points, or evidence of vessel recanalization prior to randomization; * Seizures at stroke onset; * Intracranial hemorrhage; * Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal; * Platelet count of less than 100,000 per cubic millimeter; * Severe hepatic or renal dysfunction; * Active and chronic obstructive pulmonary disease or acute respiratory distress syndrome; * \>3 L/min oxygen required to maintain peripheral arterial oxygen saturation (SaO2) 95% as per current stroke management guidelines; * Medically unstable; * Life expectancy\<90 days; * Evidence of intracranial tumor;