Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours ofā¦ (NCT05039697) | Clinical Trial Compass
CompletedNot Applicable
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onsetļ¼Longterm Outcome
China282 participantsStarted 2021-04-22
Plain-language summary
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear. The investigators' hypothesis is thatNBO is a safe and effective strategy to improve longterm outcome in AIS patients undergoing endovascular treatment.
Who can participate
Age range18 Years ā 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ā„ 18 years old.
* The clinical symptoms and signs are consistent with acute anterior circulation large vessel occlusion;
* NIHSS score ā„ 10 points;
* (Level of consciousness) NIHSS score 0 or 1;
* The time from onset to randomization is within 6 hours of onset;
* The mRS score before stroke is 0-1;
* The patient has good compliance and can complete the operation with local anesthesia;
* The patient can cooperate with this study and follow-up in the future
* Patient and family members sign informed consentć-
Exclusion Criteria:
* Rapid neurological function improvement, NIHSS score less than 10 points, or evidence of vessel recanalization prior to randomization;
* Seizures at stroke onset;
* Intracranial hemorrhage;
* Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal;
* Platelet count of less than 100,000 per cubic millimeter;
* Severe hepatic or renal dysfunction;
* Active and chronic obstructive pulmonary disease or acute respiratory distress syndrome;
* \>3 L/min oxygen required to maintain peripheral arterial oxygen saturation (SaO2) 95% as per current stroke management guidelines;
* Medically unstable;
* Life expectancy\<90 days;
* Evidence of intracranial tumor;