CompletedNot Applicable

A Study on the Brain Mechanism of cTBS in Improving Medication-resistant Auditory Hallucinations in Schizophrenia

China200 participantsStarted 2021-09-09

Plain-language summary

This study is dedicated to exploring the brain mechanism of medication-resistant auditory hallucinations and developing effective treatment methods for them by using both cross-sectional and longitudinal designs. The continuous theta burst stimulation(cTBS) treatment mode, with the left cerebellum Crus II as the stimulation target, is applied to treat the schizophrenia patients with the medication-resistant auditory hallucinations. At the same time, the first-episode schizophrenia patients with auditory hallucinations were recruited as a test cohort to examine that brain mechanism of general auditory hallucinations in schizophrenia may be the structural and functional abnormalities in the temporoparietal circuit.

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Written informed consent
✓. 18-45 years old, right-handed
✓. Meet the diagnostic criteria for schizophrenia according to the Structural Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
✓. After a sufficient course of antipsychotic treatment (more than 6 weeks, two or more antipsychotic drugs, at least one of which is the second generation of atypical antipsychotic drugs), auditory hallucinations occurred more than 5 times a day for more than 6 months
✓. Stable antipsychotic medication 4 weeks before and during the treatment (except auditory hallucination symptoms)

Exclusion criteria

✕. A history of epilepsy, convulsions, stroke or other serious brain diseases
✕. There are serious infectious diseases, malignant tumors, and severe somatic comorbidity
✕. Mental retardation, personality disorder and so on
✕

What they're measuring

Psychotic Symptom Rating Scales-Auditory Hallucination Subscale (PSYRATS-AH)

Timeframe: From baseline to 10 weeks

Structural and Function MRI data

Timeframe: From baseline to 10 weeks

Positive and Negative Syndrome Scale (PANSS)

Timeframe: From baseline to 10 weeks

Trial details

NCT IDNCT05039489

SponsorCentral South University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-31

View on ClinicalTrials.gov More Schizophrenia trials

Plain-language summary

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Written informed consent
✓. 18-45 years old, right-handed
✓. Meet the diagnostic criteria for schizophrenia according to the Structural Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
✓. After a sufficient course of antipsychotic treatment (more than 6 weeks, two or more antipsychotic drugs, at least one of which is the second generation of atypical antipsychotic drugs), auditory hallucinations occurred more than 5 times a day for more than 6 months
✓. Stable antipsychotic medication 4 weeks before and during the treatment (except auditory hallucination symptoms)

Exclusion criteria

✕. A history of epilepsy, convulsions, stroke or other serious brain diseases
✕. There are serious infectious diseases, malignant tumors, and severe somatic comorbidity
✕. Mental retardation, personality disorder and so on
✕