Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms Trial

Inclusion criteria

• . Male or female, aged 18-75
• . Diagnosis of medically refractory gastroparesis by 4 hour non-extrapolated solid phase gastric emptying study completed within 12 months of enrollment. Medical refractoriness is defined by at least 6 months of medical treatment with no significant improvement in baseline symptoms
• . Completion of all routine assessments in our multidisciplinary gastroparesis clinic, which includes evaluation by gastroenterology, behavioral health, and nutrition specialists
• . Ability to take oral medication and be willing to adhere to the post-procedure dietary and medication regimen
• . For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation
• . Stated willingness to comply with all study procedures and availability for the duration of the study
• . Willingness and reasonable expectation that the individual will be able to travel to the study site for the intervention and each scheduled in-person assessment, as well as virtual assessments if necessary
• . Be able to speak and read the English language.

Exclusion criteria