CompletedNot Applicable

A Pilot Study of Microbiome in Patients With Autism Spectrum Disorder and Their Unaffected Siblings

Taiwan150 participantsStarted 2019-01-01

Plain-language summary

The primary aims are to identify important gut microbiota signatures for youth with ASD, to identify dysbiosis features for different levels of ASD features and clinical courses, to search the possibility to intervene the disease course if we can tease out the dysbiosis responsible for the flare-up and improvement of the symptoms of the disease. The secondary aims are to identify the clinical and neuropsychological measures that are associated with direct and indirect regulation or interactions from gut-brain axis signaling, and based our preliminary results on reducing the measures for future large-scale microbiome study in ASD.

Who can participate

Age range7 Years – 25 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * a clinical diagnosis of ASD defined by the DSM-IV confirmed by ADI-R or ADOS and also clinical reappraisal based on the newly release DSM-5 criteria for ASD * ages range from 7 to 25 at the time now * at least one biological parent * parents that are both Han Chinese in Taiwan Exclusion Criteria: * intellectual disability * epilepsy * ADHD * autoimmune diseases

What they're measuring

Autism Diagnostic Interview-Revised (ADI-R)

Timeframe: 1 hour

Autism Diagnostic Observation Scale (ADOS)

Timeframe: 1 hour

Trial details

NCT IDNCT05038748

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-31

View on ClinicalTrials.gov More Autism Spectrum Disorder trials