Stopped: Discontinuation of funding.
This is an imaging study designed to illuminate the function of the cholinergic system and its association with cognitive skills in people with Parkinson's disease. The hypothesis of this study is that there will be an association between cholinergic terminal density, sex hormones, and cognitive functioning. Participants will receive a PET and MRI scan along with a battery of neurocognitive tests at baseline and again at 18 months follow-up. Hormone levels will be measured at baseline.
Age range
50 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Cholinergic terminal density at baseline
Timeframe: Baseline
Cholinergic terminal density change between baseline and 18-months follow-up
Timeframe: Baseline and 18 months follow-up
Overall cognitive functioning at baseline
Timeframe: Baseline
Change in overall cognitive functioning
Timeframe: Baseline and 18 Months
Attention/working memory at baseline as measured by the Trail Making A Test
Timeframe: Baseline
Attention/working memory change from baseline to 18-months follow-up as measured by the Trail Making A Test
Timeframe: 18 months
Attention/working memory at baseline as measured by the Symbol Digit Modalities Test (SDMT)
Timeframe: Baseline
Attention/working memory change from baseline to 18-months follow-up as measured by the Symbol Digit Modalities Test
Timeframe: Baseline and 18- months follow-up
Executive function at baseline as measured by the Clock Drawing Test
Timeframe: Baseline
Executive function change from baseline to 18-months follow-up as measured by the Clock Drawing Test
Timeframe: Baseline and 18-month follow-up
Executive function at baseline as measured by the Trail Making Test B
Timeframe: Baseline
Executive function change from baseline to 18-months follow-up as measured by the Trail Making Test B
Timeframe: Baseline and 18-month follow-up
Language at baseline as measured by the Animal Naming Test
Timeframe: Baseline
Language change from baseline to 18-month follow-up as measured by the Animal Naming Test
Timeframe: Baseline and 18-months follow-up
Language at baseline as measured by the Boston Naming Test
Timeframe: Baseline
Language change from baseline to 18-months follow-up as measured by the Boston Naming Test
Timeframe: Baseline and 18-months follow-up
Language change between baseline and 18-month follow-up as measured by the Boston Naming Test
Timeframe: Baseline
Memory at baseline as measured by the Free and Cued Selective Reminding Test
Timeframe: Baseline
Memory change from baseline to 18-months follow-up as measured by the Free and Cued Selective Reminding Test
Timeframe: Baseline and 18-months follow-up
Memory at baseline as measured by the Brief Visuospatial Memory Test-Revised Selective Reminding Test
Timeframe: Baseline
Memory change from baseline to 18-months follow-up as measured by the Brief Visuospatial Memory Test-Revised
Timeframe: Baseline and 18-months follow-up
Memory change between baseline and 18-month follow-up
Timeframe: Baseline and 18-month follow-up
Visuospatial at baseline as measured by the Judgement of Line Orientation Test
Timeframe: Baseline
Visuospatial change from baseline to 18-months follow-up as measured by the Judgement of Line Orientation Test
Timeframe: Baseline and 18-months follow-up
Visuospatial at baseline as measured by the Intersecting Pentagons Test
Timeframe: Baseline
Visuospatial change from baseline to 18-months follow-up as measured by the Intersecting Pentagons Test
Timeframe: Baseline and 18-months follow-up
Estrogen levels in blood at baseline
Timeframe: Baseline
Progesterone levels in blood as baseline
Timeframe: Baseline
Testosterone levels in blood at baseline
Timeframe: Baseline