Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS

Inclusion Criteria: * Age of at least 18 years. * Diagnosis of acute coronary syndrome. * Single or multiple intermediate lesions in intervention-naïve major coronary segments (diameter ≥2.5 mm) determining a 40-70% diameter stenosis by visual assessment with no other significant stenosis (\>70%) in the same vessel. * Patient informed of the nature of the study, agreeing to it, and providing written informed consent as approved by the Ethics Committee of the respective clinical study site. * Life expectancy \>3 years. Exclusion criteria: * Female with childbearing potential or lactating. * Acute or chronic renal dysfunction (defined as creatinine greater than 2.0 mg/dl). * Advanced heart failure (NYHA III-IV) * Stroke within the previous 6 months or spontaneous intracranial hemorrhage at any time. * Severe valvular disease or valvular disease likely to require surgery or percutaneous valve replacement during the trial. * Coronary anatomy preventing complete imaging of the segment of interest (including at least 5 mm at both stenosis edges). * Lesions located in the left main coronary artery * Diffusely diseased coronary artery segment or presence of ≥1 significant untreated non-culprit lesions (preventing correct adverse event attribution) in the coronary arteries. * Prior myocardial infarction or coronary artery bypass graft \[CABG\] or PCI revascularization in the target coronary vessel. * Coronary anatomy unsuitable for PCI. * Comorbidities that might interfere with com…